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    當前位置:首頁技術文章重組白介素IL12 P80 Murine IL-12 p80

    重組白介素IL12 P80 Murine IL-12 p80

    更新時間:2013-06-17點擊次數:1483

    Synonyms :

    none

    Description :

    IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant murine IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

    Catalog #:

    210-12p80

    Source :

    CHO cellls

    Stability :

    The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted IL-12 p80 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles

    Purity :

    Greater than 98% by SDS-PAGE gel and HPLC analyses.

    Endotoxin Level :

    Endotoxin level is less than 0.1 ng per μg (1EU/μg).

    Biological Activity :

    Not Available.

    AA Sequence :

    p40 Monomer: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS

    PubMed Link :

    IL-12+AND+p80+AND+mouse

    Country of Origin :

    USA

     

     

    Size A 2µg $75   
     
    Size B 10µg $185