技術文章
Technical articles
更新時間：2013-06-17
點擊次數：1581
| Synonyms : | BMP-2B, DVR4 | ||||||||||||||||
| Description : | Bone morphogenetic proteins （BMPs） constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Recombinant human BMP-4, expressed in HeLa cells, is a 31-36 kDa homodimeric glycoprotein. | ||||||||||||||||
| Catalog #: | 120-05 | ||||||||||||||||
| Source : | HeLa cells | ||||||||||||||||
| Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted BMP-4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles. | ||||||||||||||||
| Purity : | Greater than 97% by SDS-PAGE gel and HPLC analyses. | ||||||||||||||||
| Endotoxin Level : | Endotoxin level is less than 0.1 ng per μg （1EU/μg）. | ||||||||||||||||
| Biological Activity : | Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. | ||||||||||||||||
| AA Sequence : | HHSQRARKKN KNCRRHSLYV DFSDVGWNDW IVAPPGYQAF YCHGDCPFPL ADHLNSTNHA IVQTLVNSVN SSIPKACCVP SAISMLY LDEYDKVVLK NYQEMVVEGC GCR | ||||||||||||||||
| PubMed Link : | BMP-4 | ||||||||||||||||
| Country of Origin : | USA | ||||||||||||||||
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